| 钴(Ⅱ)、镍(Ⅱ)、铜(Ⅱ)、锌(Ⅱ)的双-N(2-羟基乙基)水杨醛亚胺螯合物的合成及其抗癌活性的初步试验 |
| SYNTHESIS FOR CHELATES OF 2-HOC6H4 (CHNCH2CH2OH) WITH Co(Ⅱ),Ni(Ⅱ),Cu(Ⅱ),Zn(Ⅱ) AND PRIMARY TESTS OF THEIR ANTICANCER ACTIVITIES |
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| 摘要: 合成了-N(2-羟基乙基)水杨醛亚胺合钴(Ⅱ)、镍(Ⅱ)、铜(Ⅱ)和锌(Ⅱ)并为元素分析和红外光谱数据所表征。其中三种螯合物为新的席地夫碱金属配合物。用体外美兰法对Co(Ⅱ)、Ni(Ⅱ)和Cu(Ⅱ)配合物进行了抗癌活性试验。结果表明,这些螯合物对六种人体肿瘤具有抑瘤活性。 |
| 关键词: 亚胺 席夫碱 癌 |
| 基金项目: |
| Abstract: The chelates of 2-HOC6H4 (CHNCH2CH2OH) with Co(Ⅱ), Ni(Ⅱ), Cu (Ⅱ), Zn(Ⅱ) have been synthesized and characterized by elemental analysis and infrared spectral data. Three of these metal chelates are new schiff base metal complexes. Complexes of Co(Ⅱ), Ni(Ⅱ) and Cu(Ⅱ) have been tested for their anticancer activities by methylene blue method in vitro. The results showed that these chelates displayed carcinostatic activities in the treatment of 6 types of human tumour. |
| Keywords: inline schiff base cancer |
| 投稿时间：1984-10-24 |
| 摘要点击次数: 1907 |
| 全文下载次数: 1440 |
| 吴自慎,严振寰,刘谨懋,周园林,刘珍意,郑芙蓉,高小海,张先林.钴(Ⅱ)、镍(Ⅱ)、铜(Ⅱ)、锌(Ⅱ)的双-N(2-羟基乙基)水杨醛亚胺螯合物的合成及其抗癌活性的初步试验[J].无机化学学报,1986,2(1):108-112. |
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