| 2－羰基丙酸(2, 4－二硝基苯基)腙镧系配合物的合成及其大鼠精子抑制效应研究 |
| LANTHANIDE(Ⅲ)COMPLEXES WITH 2-CARBONYLPROPIONYL(2, 4-DINITRO PHENYL)HYDRAZONE:SYNTHESIS AND STUDY ON THE MOUSE-SPERM INHIBITION EFFECT |
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| 摘要: 本文合成了12种镧系配合物Ln(CPD)3·2H2O[Ln=La～Yb,除Pm、Tm;HCPD=2-羰基丙酸(2,4-二硝基苯基)腙].对配合物进行了元素分析、差热-热重分析;测定了其红外光谱、紫外光谱、核磁共振谱(1H和13C)、磁化率和摩尔电导.给出了配合物可能的结构,并对镧配合物进行了大鼠精子抑制效应的研究. |
| 关键词: 镧系配合物 合成 精子抑制效应 |
| 基金项目: |
| Abstract: In this paper, twelve lanthanide(Ⅲ)complexes. with the general formula Ln(CPD)32H2O(Ln=La-Yb, except Pm and Tm;HCPD=2-carbonylpropicnyl(2,4-dintirophenyl)hydrazone), have been synthesized and characterized on the basis of clemental analyses;TG-DTA;TR. UV. 1H NMR and 13C NMR spectra;magnetic moment and molar conductance measurements. The proposed structure for these complexes is given. by showing that the carboxylate group bound to Ln3+ ion with a bidentate coordination type. The preliminary pharmacological results demonstrated that the lanthanum complex La(CPD)3·2H2O exhibited mouse-sperm inhibition effects. |
| Keywords: lanthanide(Ⅲ)complex synthesis mouse-sperm inhibition effect |
| 投稿时间：1994-12-06 |
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| 沈旭,谢毓元,杨传俊,顾芝萍.2－羰基丙酸(2, 4－二硝基苯基)腙镧系配合物的合成及其大鼠精子抑制效应研究[J].无机化学学报,1995,11(4):371-377. |
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