| 希土化合物对离体巨噬细胞的影响 |
| EFFECT OF RARE EARTH COMPOUNDS TO ALVEOLAR MACROPHAGE IN VITRO |
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| 摘要: 本文应用细胞培养法和单细胞阳离子测定系统研究了希上化合物对巨噬细胞的影响.结果表明,在培养介质中SmCl3和YCl3的浓度大于1mmol·dm-3时,有明显的细胞毒性,YCl3的细胞毒性大于SmCl3.SmCl3和YCl3的细胞毒性明显大于Sm(Ala)3Cl3和Y(Ala)2Cl3希土化合物的作用使细胞[Ca2+]i升高;毒性越大,[Ca2+]i升高越甚.低浓度Sm3+和Y3+对细胞膜Ca2+-ATP酶有激活作用. |
| 关键词: 希土化合物 细胞毒性 胞浆游离Ca2+ Ca2+－ATP酶 |
| 基金项目: 江西省青年科学基金 |
| Abstract: Using cell incubation and AR-CM-MIC Canon Mcasurcmcnt System, the effect of rare earth compounds to alveolar macrophage was studied in vitro. The results arc mainly as follows: lmmol·dm-3SmCl3, or YCl3 in incubation medium has obvious cytotoxicity. The cytotoxicity of YCl3, is greater than that of SmCl3. The cytotoxicity of SmCl3 or YCl3 is greater than that of Sin(Ala)3Cl3 or Y(Ala)2Cl3. The poisonous action of rare earth compounds to alveolar macrophage leads to the increase of [Ca2+]. The greater the cytotoxicity, the greater the increase of [Ca2+]. Sm3+ and Y3+ can activate the Ca2+-ATPase of crythrocytic membrane. |
| Keywords: rare earth compound cytotoxicity cytoplasmic Ca2+ Ca2+-ATPase |
| 投稿时间：1994-12-21 |
| 摘要点击次数: 1335 |
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| 温和瑞,郭国瑞,朱卫华,王金晞.希土化合物对离体巨噬细胞的影响[J].无机化学学报,1995,11(4):389-393. |
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