| 大环铜(Ⅱ)配合物与DNA结合的ESR及自旋捕获测定 |
| MACROCYCLIC COPPER (Ⅱ) ASSEMBLY WITH DNA STUDIED BY ELECTRON SPIN RESONANCE AND SPIN TRAPPING |
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| 摘要: 与DNA结合前后的大环铜(Ⅱ)配合物(CuL2+，如图1所示)ESR谱表明CuL2+与DNA碱基有配位作用。以DMPO为自旋捕获剂进行的自旋捕获实验则证实了活性氧中间产物·OH的存在，在CuL2+的引导下导至DNA氧化损伤。 |
| 关键词: 大环铜(Ⅱ)配合物 DNA ESR 自旋捕获 |
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| Abstract: The electron spin resonance spectra of macrocyclic copper (Ⅱ) and its assembly with DNA have suggested that the base in the DNA is coordinated to copper (Ⅱ). The presence of active oxygen intermediate ·OH has been indicated by spin trapping experiment by use of DMPO as spin trapping agent. DNA oxidative damage is caused by the active oxygen species by the copper (Ⅱ)-mediation. |
| Keywords: copper (Ⅱ) macrocycle DNA ESR spin trapping |
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| 刘长林,周井炎,徐辉碧.大环铜(Ⅱ)配合物与DNA结合的ESR及自旋捕获测定[J].无机化学学报,1998,14(3):253-256. |
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