| 一种新型Au(Ⅲ)-吡啶酰胺配合物的合成，表征及其与5′-单磷酸鸟苷的反应研究 | |
| Synthesis and Characterization of a Novel Au(Ⅲ)-Pyridine-Carboxamide Complex and its Reaction with 5′-GMP | |
| 摘要: 利用四氯合金酸和N-4-甲基苯基2-吡啶甲酰胺(HL)反应，合成得到了一种新的Au(Ⅲ)配合物：二氯(N-4-甲基苯基2-吡啶甲酰胺合金(Ⅲ)[Au(L-N，N′)Cl2]。并通过元素分析、红外光谱、核磁共振谱、质谱及X-射线单晶衍射对其进行了表征。结构分析表明，Au(Ⅲ)由二个氮原子和二个氯原子配位，呈平面四方形结构。质谱研究发现，该化合物与5′-单磷酸鸟苷(5′-GMP)反应生成[Au(L-N，N′)(5′-GMP)2]。 | |
| 关键词: 三价金Au(Ⅲ) 合成 晶体结构 5′-GMP | |
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| Abstract: The Au(Ⅲ)has the isoelectric structure to Pt(Ⅱ)， and its complexes may possess potential antitumor activity. In this work we have synthesized and structurally characterized a novel Au(Ⅲ) compound with N-(4-Methylphenyl)-2-pyridine -carboxamide (HL) [Au(L-N，N′)Cl2]. The X-ray structural analysis shows that Au(Ⅲ) is coordinated in a square planar geometry with two N atoms of the ligand and two Cl atoms. The compound is crystallized in monoclinic， space group is P2(1)/c with a=0.8464(2)nm， b=2.7823(6)nm， c=1.2161(2)nm， α= 90.000°， β=104.130(3)°， γ=90.000°. The ESMS data show that the Au(Ⅲ) compound can react with 5′-GMP to give rise formation of the bis-GMP adduct [Au(L-N，N′)(5′-GMP)2]. CCDC： 194629. | |
| Keywords: Au(Ⅲ) synthesis crystal structure 5′-GMP | |
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| 杨婷,张俊勇,涂超,林骏,刘琴,郭子建.一种新型Au(Ⅲ)-吡啶酰胺配合物的合成，表征及其与5′-单磷酸鸟苷的反应研究[J].无机化学学报,2003,19(1):45-48. | |
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