| Cu(Ⅱ)，Ni(Ⅱ)，Co(Ⅱ)，Mn(Ⅱ)，Zn(Ⅱ)和Cd(Ⅱ)的乙基3-(2-氨硫化亚肼基)-2-(羟胺基)丁烯酸酯配合物：合成、表征和细胞毒性 |
| Cu(Ⅱ), Ni(Ⅱ), Co(Ⅱ), Mn(Ⅱ), Zn(Ⅱ) and Cd(Ⅱ) Complexes of Ethyl-3-(2-carbamothioylhydrazono)-2-(hydroxyimino)butanoate： Synthesis, Characterization and Cytotoxicity Activity |
| 作者 | 单位 | E-mail | | Ramadan M El Bahnasawy | Chemistry Department, Faculty of Science, Menoufia University, Shebin El-Kom, Egypt | | | Abdou S El-Tabl | Chemistry Department, Faculty of Science, Menoufia University, Shebin El-Kom, Egypt | asaeltabl@yahoo.com | | Mohamad M E Shakdofa | Chemistry Department, Faculty of Science and Arts, Khulais, King Abdulaziz University Saudi Arabia
Inorganic Chemistry Department, National Research Center, P. O. 12622 Dokki, Cairo, Egypt | | | Noran M Abd El-Wahed | Chemistry Department, Faculty of Science, Menoufia University, Shebin El-Kom, Egypt | |
|
| 摘要: 合成了Cu(Ⅱ)，Ni(Ⅱ)，Co(Ⅱ)，Mn(Ⅱ)，Zn(Ⅱ)和Cd(Ⅱ)的乙基3-(2-氨硫化亚肼基)-2-(羟胺基)丁烯酸酯配合物(H2L)并用元素分析，DTA热分析，IR，UV-Vis，1H-NMR，质谱，顺磁共振以及磁矩，电导率测量等对合成的配合物进行表征。摩尔电导率测量结果证明合成的配合物为非电解质。光谱数据表明配体分别表现为一元的三齿配体，一元的二齿配体，中性的二齿配体，中性的三齿配体，一元的四齿配体或二元的四齿配体通过席夫碱的氮原子，氨基硫脲中的氮原子，肟中的氮原子和硫酮中的硫原子与金属离子键合生成围绕金属离子的四面体或平面正方形构型。固态Cu(Ⅱ)(2)，(3)，(4)和(5)的配合物顺磁共振谱表明其为轴向对称，但(10~15)的配合物却为各向异性。配体和配合物(2)，(3)，(10)，(13)，(16)和(19)由于它们对乳腺癌(MCF-7细胞系)和肝癌(HePG-2细胞系)的抑制作用而表现出潜在的抗癌活性。 |
| 关键词: 缩氨基硫脲 肟 配合物 光谱研究 磁性 细胞毒性 |
| 基金项目: |
| Abstract: Cu(Ⅱ), Ni(Ⅱ), Co(Ⅱ), Mn(Ⅱ), Zn(Ⅱ) and Cd(Ⅱ) complexes of ethyl-3-(2-carbamo thioylhydrazono)-2-(hydroxyimino)butanoate (H2L) have been synthesized and characterized by elemental and thermal (DTA) analyses, IR, UV-Vis spectroscopy, 1H-NMR, mass and ESRspectra as well as magnetic moments, conductivity measurements. The molar conductance measurements indicate that the complexes are non-electrolytes in nature. The spectral data show that the ligand behaves as monobasic tridentate, monobasic bidentate, neutral bidentate, neutral tridentate, monobasic tetradentate or dibasic tetradentate bonded to the metal ions via azomethine nitrogen atom, nitrogen atom of thiosemicarbazide moiety, nitrogen atom of oxime moiety and thione sulphur atom forming octahedral or square planar geometry around the metal ions. The ESRspectra of solid copper(Ⅱ) complexes (2), (3), (4) and (5) show axial type symmetry, however, complexes (10~15) show isotropic type. The ligand and complexes (2), (3), (10), (13), (16) and (19) show potential antitumor activity due to their inhibitory effect on breast carcinoma (MCF-7 cell line) and hepatocellular cancer (HePG-2 cell line). |
| Keywords: Thiosemicarbazone oxime complexes spectral studies magnetism and cytotoxicity activity |
| 投稿时间：2013-10-17 修订日期：2013-12-25 |
| 摘要点击次数: 1963 |
| 全文下载次数: 1364 |
| Ramadan M El Bahnasawy,Abdou S El-Tabl,Mohamad M E Shakdofa,Noran M Abd El-Wahed.Cu(Ⅱ)，Ni(Ⅱ)，Co(Ⅱ)，Mn(Ⅱ)，Zn(Ⅱ)和Cd(Ⅱ)的乙基3-(2-氨硫化亚肼基)-2-(羟胺基)丁烯酸酯配合物：合成、表征和细胞毒性[J].无机化学学报,2014,30(6):1435-1450. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| Support information: 相关附件： file130765_supplenentary.pdf |
|
|
|
|
|
|
